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Updated: Jun 19, 2025

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Insulin icodec: A novel once-weekly treatment for diabetes
Hannah Schaffner1, Jordyn Wiener2, Amanda DeLuca2
1East Coast Institute for Research, Jacksonville, Florida, USA.
Aims:
To summarize the results of clinical studies of insulin icodec, an investigational insulin analog designed for once-weekly administration, in adults with type 1 and type 2 diabetes.
Methods:
Thirteen published articles describing clinical studies of insulin icodec were identified in PubMed, and data pertinent to key study outcomes were selected for inclusion in this review.
Results:
In insulin-naïve and insulin-treated individuals, icodec demonstrated efficacy in glycaemic control superior or noninferior to that of insulins glargine U100, glargine U300 and degludec. Icodec exhibited a safety profile comparable to marketed insulins, with the exception of hypoglycaemic event rates.
Conclusions:
As a once-weekly alternative to daily basal insulin, icodec is expected to improve patient adherence and satisfaction, reducing the required number of injections per year from 365 to 52 and providing a dosing option potentially attractive to a wide range of insulin users. However, clinical data suggest a notable risk of hypoglycaemia with weekly icodec administration, especially in individuals with type 1 diabetes.
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