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Related Experiment Video

Updated: Jun 19, 2025

BioMEMS: Forging New Collaborations Between Biologists and Engineers

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

Spiers Memorial Lecture: Engineering biocatalysts.

Donald Hilvert¹

¹Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland. hilvert@ethz.ch.

Faraday Discussions

|July 24, 2024

Summary

This summary is machine-generated.

Designer enzymes are engineered to perform novel chemical reactions, offering significant potential in biotechnology and medicine. Research focuses on creating new enzymes with enhanced reactivity and selectivity beyond natural capabilities.

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Last Updated: Jun 19, 2025

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Area of Science:

Biochemistry and Biotechnology
Protein Engineering
Synthetic Biology

Background:

Enzymes are crucial biological catalysts with diverse applications.
Current research focuses on engineering enzymes for novel chemical reactions.
Methods are explored to access reactivities not found in native enzymes.

Discussion:

Review of approaches for enzyme engineering.
Emphasis on methods to achieve non-native reactivities.
Highlighting the creation of completely de novo enzymes.

Key Insights:

Engineered enzymes can rival natural counterparts in rate and selectivity.
De novo enzyme design demonstrates significant potential.
Successful engineering unlocks new catalytic possibilities.

Outlook:

Designer enzymes show promise for research, industry, and medicine.
Challenges in realizing the full potential of engineered enzymes are discussed.
Potential solutions and future directions are considered.