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Updated: Jun 19, 2025
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Intravenous Injections in Neonatal Mice
Published on: November 11, 2014
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Patient Preference for Subcutaneous Versus Intravenous Administration with Every-6-Week Natalizumab (Tysabri®)
Heinz Wiendl1, John Foley2, Gilles Defer3
1Department of Neurology with Institute of Translational Neurology, University of Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany. heinz.wiendl@ukmuenster.de.
Neurology and Therapy
|July 24, 2024
Summary
Most patients with multiple sclerosis preferred subcutaneous natalizumab over intravenous infusions. The subcutaneous route, administered every 6 weeks, was favored for its convenience and reduced clinic time.
Area of Science:
- Neurology
- Pharmacology
- Clinical Trials
Background:
- The NOVA phase IIIb study (part 2) evaluated patient preference for subcutaneous (SC) versus intravenous (IV) natalizumab.
- This extension phase followed the approval of SC natalizumab and aimed to collect patient preference data for every-6-week (Q6W) dosing.
Purpose of the Study:
- To assess patient preference between SC and IV natalizumab administration.
- To explore efficacy, safety, and pharmacology of both natalizumab administration routes.
Main Methods:
- Participants received IV natalizumab (300 mg) Q6W for 36 weeks.
- A 48-week crossover treatment phase involved 24 weeks of SC Q6W and 24 weeks of IV Q6W natalizumab.
Main Results:
- Out of 123 participants with preference data, 108 (87.8%) preferred SC natalizumab.
- The primary reason for SC preference was reduced clinic time, cited by 102 participants (82.9%).
Conclusions:
- The majority of participants in the NOVA part 2 study preferred SC natalizumab administration over IV administration.
- SC natalizumab offers a patient-preferred alternative for Q6W dosing.
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