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Updated: Jun 19, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Significant pituitary siderosis is common in transfusion-dependent sickle cell disease
Akhila Vadivelan1, Eamon K Doyle2,3, Susan Carson4
1Division of Pediatric Hematology/Oncology, Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, CA.
Abstract:
Chronically transfused patients with sickle cell disease typically do not exhibit iron-mediated extrahepatic toxicity. However, we demonstrate that the pituitary gland is vulnerable to iron deposition, and it occurs regardless of other extrahepatic involvement. Severe pituitary siderosis is associated with early organ dysfunction.
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