Early-Life Factors Associated With Adult-Onset Type 1 Diabetes: A Swedish Nationwide Cohort and Family-Based Study
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View abstract on PubMed
Summary
This summary is machine-generated.Parental history of type 1 diabetes (T1D) and birth year are linked to adult-onset T1D. Perinatal factors play a minor role, suggesting later-life triggers are more significant for adult T1D development.
Area Of Science
- Endocrinology
- Epidemiology
- Genetics
Background
- Childhood-onset type 1 diabetes (T1D) is linked to perinatal factors.
- Data on adult-onset T1D and early-life influences are limited.
Purpose Of The Study
- Investigate associations between early-life factors and adult-onset T1D.
- Utilize a Swedish nationwide cohort and family-based study.
Main Methods
- Included over 1.8 million individuals aged 18+, born 1983-2002, followed until 2020.
- Used national registers for T1D diagnosis and perinatal exposures.
- Employed Cox regression and sibling comparison analyses.
Main Results
- Adult-onset T1D incidence was 18.8 per 100,000 person-years.
- Maternal/paternal T1D history and later birth year increased risk.
- Female sex and immigrant parents decreased risk; non-full-term birth showed a minor increase.
Conclusions
- Perinatal factors have a limited role in adult-onset T1D.
- Later-life triggers or accelerators of autoimmunity are likely more critical.
- Findings contrast with established factors for childhood-onset T1D.
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