Unraveling the role of computed tomography derived body composition metrics on anastomotic leakages rates in rectal cancer surgery: A protocol for a systematic review and meta-analysis
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Summary
This summary is machine-generated.This systematic review examines computed tomography (CT) derived body composition metrics and their impact on anastomotic leakage rates in rectal cancer patients after total mesorectal excision. Findings will clarify conflicting evidence and aid pre-operative decision-making.
Area Of Science
- Oncology
- Radiology
- Surgical Outcomes
Background
- Anastomotic leakage is a significant complication after rectal cancer surgery (total mesorectal excision), impacting patient outcomes and healthcare costs.
- Existing literature on the influence of body composition on anastomotic leakage rates is conflicting.
- Computed tomography (CT) derived body composition metrics are increasingly recognized but their specific role in rectal cancer surgery requires clarification.
Purpose Of The Study
- To systematically review and evaluate the role of CT-derived body composition metrics in predicting anastomotic leakage rates in rectal cancer patients.
- To synthesize current evidence and identify knowledge gaps regarding body composition and surgical outcomes.
Main Methods
- Systematic literature search of PubMed/MEDLINE, Cochrane Library, Web of Science, and EMBASE from January 2010 onwards.
- Independent study selection, data collection, and quality assessment by three research fellows.
- Meta-analysis of outcomes reported in three or more studies, with heterogeneity assessed using Q-test and I2 statistic; publication bias evaluated using funnel plots and Egger's test.
Main Results
- This section will be populated upon completion of the systematic review and meta-analysis.
- The review will synthesize findings on specific CT-derived body composition metrics (e.g., skeletal muscle index, adipose tissue areas) and their association with anastomotic leakage.
- Statistical analysis will quantify the pooled effect of these metrics on leakage rates, if sufficient data exists.
Conclusions
- The systematic review will provide a comprehensive synthesis of current evidence on CT-derived body composition metrics and anastomotic leakage in rectal cancer.
- Results are expected to aid healthcare professionals in pre-operative risk stratification and patient management.
- Findings will be disseminated through peer-reviewed publication and international conference presentations.
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