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The ISR downstream target ATF4 represses long-term memory in a cell type-specific manner

Niaz Mahmood1,2, Jung-Hyun Choi1,2, Pei You Wu3

  • 1Department of Biochemistry, McGill University, Montréal, QC H3A 1A3, Canada.

Proceedings of the National Academy of Sciences of the United States of America
|July 24, 2024
PubMed
Summary

Activating transcription factor 4 (ATF4), a key part of the integrated stress response (ISR), represses long-term memory (LTM) formation. Removing ATF4 from excitatory neurons enhances LTM and boosts energy production pathways.

Keywords:
integrated stress responselearning and memoryprotein synthesissynaptic plasticity

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