Related Experiment Video
Updated: May 2, 2026

07:43
Assaying Proteasomal Degradation in a Cell-free System in Plants
Published on: March 26, 2014
14.5K
Photoswitchable Auxin-Inducible Degron System for Conditional Protein Degradation with Spatiotemporal Resolution
Saugata Sahu1, Koya Yoshizawa2, Takahiro Yamamoto2
1Research Institute for Electronic Science, Hokkaido University, Sapporo 001-0020, Japan.
Journal of the American Chemical Society
|July 24, 2024
Abstract:
The auxin-inducible degron (AID) system degrades target proteins rapidly in a controllable manner. Although this is a highly versatile technique for studying protein functionality, protein degradation with spatiotemporal resolution is not currently possible. Herein we describe a photoswitchable AID using a light-active auxin derivative for reversible and site-specific protein degradation with temporal resolution.

