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Nasal clear cell chondrosarcoma in a dog
Megan Moloney1, Melanie Dobromylskyj2, César Sanchez-Jimenez1
1Lumbry Park Veterinary Specialists, Selborne Rd, Alton GU34 3HL, Hampshire, UK.
Journal of Comparative Pathology
|July 24, 2024
Summary
A rare clear cell chondrosarcoma (CCC) was diagnosed in a dog's nasal cavity. This finding suggests the nasal area may be a specific site for this uncommon canine tumor.
Area of Science:
- Veterinary Pathology
- Canine Oncology
Background:
- Intranasal tumors in dogs can present with clinical signs such as epistaxis and nasal discharge.
- Clear cell chondrosarcoma (CCC) is a rare chondroid tumor characterized by clear or vacuolated cells.
Purpose of the Study:
- To report a case of intranasal clear cell chondrosarcoma (CCC) in a dog.
- To discuss the potential species-specific predilection site for this rare canine neoplasm.
Main Methods:
- A 5-year-old crossbreed dog presented with epistaxis and nasal discharge.
- Computed tomography (CT) identified a right nasal cavity mass.
- Histological examination and immunohistochemistry (IHC) were performed for definitive diagnosis.
Main Results:
- Histopathology revealed sheets of clear to vacuolated cells with intracytoplasmic glycogen.
- Immunohistochemistry showed tumor cells positive for vimentin and S100, and negative for pancytokeratin, Melan-A, and PNL2.
- Diagnosis confirmed as clear cell chondrosarcoma (CCC).
Conclusions:
- This case represents a rare instance of canine nasal clear cell chondrosarcoma (CCC).
- The nasal cavity may be a predilection site for this rare canine tumor, as suggested by this and one prior report.
- Further investigation is warranted to understand the occurrence of CCC in canine nasal passages.
