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Collaborative robotics to enable ultra-high-throughput IR-MALDESI.

John Shanley1, Fan Pu1, Jon D Williams1

  • 1AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064.

SLAS Technology
|July 24, 2024
PubMed
Summary
This summary is machine-generated.

A new robotic system automates sample transfer for Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry (IR-MALDESI-MS), enabling rapid screening of millions of compounds. This high-throughput method significantly accelerates biochemical and cellular assay analysis.

Keywords:
Ambient ionization mass spectrometryCollaborative roboticsInfrared matrix-assisted laser desorption electrospray ionization mass spectrometryRedox cycling compoundsUltra-high-throughput Screening

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Area of Science:

  • Mass Spectrometry
  • Biochemistry
  • Robotics

Background:

  • Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry (IR-MALDESI-MS) offers high-throughput analysis with acquisition rates up to 22 Hz per plate.
  • The rate-limiting step in IR-MALDESI-MS is the speed of sample plate transfer to the instrument.

Purpose of the Study:

  • To develop a system for rapid and safe transfer of assay plates to IR-MALDESI-MS.
  • To enhance the overall throughput of high-throughput screening assays.

Main Methods:

  • Development of a collaborative robotic plate transfer system (CRPTS) integrating a 6-axis robot, dual plate grippers, and a 7th axis conveyor.
  • Implementation of a 420-plate capacity sample loading window.
  • Demonstration using a biochemical assay monitoring tris(2-carboxyethyl)phosphine (TCEP) oxidation for nuisance compound screening.

Main Results:

  • Analysis of 158,799 compounds across 448 plates in 12.5-17.5 hours using continuous and step motion scan profiles.
  • Achieved high Z-Factors (0.87 and 0.99), indicating assay reliability.
  • Demonstrated throughput enabling the screening of a million compounds within 6-7 working days.

Conclusions:

  • The CRPTS significantly overcomes the plate transfer bottleneck in IR-MALDESI-MS.
  • This automated system enables ultra-high-throughput compound screening.
  • The technology has the potential to accelerate drug discovery and chemical biology research.