Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

193
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
193
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

1.5K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.5K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
Asthma-I: Introduction01:29

Asthma-I: Introduction

2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating current bronchiectasis care in Italy according to the 2025 European respiratory society recommendations.

Therapeutic advances in respiratory disease·2026
Same author

Clinical impact of mucus plugs in bronchiectasis.

Scientific reports·2026
Same author

KL-6 as a Biomarker for Adult Patients with Cystic Fibrosis and the Impact of <i>MUC1</i> Genotype.

Journal of clinical medicine·2026
Same author

The importance of symptoms in bronchiectasis.

European respiratory review : an official journal of the European Respiratory Society·2026
Same author

ERS statement: Core outcome set for trials evaluating the management of community-acquired and nosocomial pneumonia in adults.

The European respiratory journal·2026
Same author

Association of German Bronchiectasis Registry participation with disease course.

ERJ open research·2026

Related Experiment Video

Updated: Jun 19, 2025

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

645

Exacerbations of bronchiectasis.

Alessandro De Angelis1,2, Emma D Johnson3, Sivagurunathan Sutharsan4

  • 1Department of Biomedical Sciences, Humanitas University, Milan, Italy.

European Respiratory Review : an Official Journal of the European Respiratory Society
|July 24, 2024
PubMed
Summary
This summary is machine-generated.

This review synthesizes current knowledge on bronchiectasis exacerbations, emphasizing early recognition, tailored treatments, and improved patient outcomes for this complex respiratory condition.

More Related Videos

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K
A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
05:56

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

Published on: May 12, 2023

3.4K

Related Experiment Videos

Last Updated: Jun 19, 2025

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD
04:03

Author Spotlight: Evaluating the Therapeutic Efficacy of Moving Cupping Along Meridians for Acute Exacerbation of COPD

Published on: September 27, 2024

645
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

31.9K
A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
05:56

A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion

Published on: May 12, 2023

3.4K

Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Review

Background:

  • Bronchiectasis is a chronic respiratory condition with increasing prevalence, significant economic impact, and diverse clinical presentations.
  • Exacerbations represent a critical challenge, impacting patient outcomes and disease progression.
  • Understanding the transition from stable states to exacerbations is crucial for effective management.

Purpose of the Study:

  • To synthesize contemporary understanding and literature on bronchiectasis exacerbations.
  • To highlight the importance of early recognition, severity assessment, prompt treatment, and prevention strategies.
  • To explore novel approaches for improving patient outcomes, including precision medicine.

Main Methods:

  • Comprehensive literature review of bronchiectasis exacerbations.
  • Analysis of pathophysiology, including microbial/nonmicrobial triggers and comorbidities.
  • Exploration of "exogenous and endogenous changes in airways homeostasis" and the "adapted island model".

Main Results:

  • Identified "frequent exacerbators" as a distinct patient group with worse outcomes.
  • Elaborated on the interplay between stable phases and exacerbations.
  • Detailed the impact of exogenous insults (infections, pollution) and endogenous factors (inflammatory endotypes).

Conclusions:

  • A multidisciplinary approach integrating precision medicine and biomarker research is essential for tailored bronchiectasis treatments.
  • Challenging the traditional antibiotic paradigm is necessary for improved patient care.
  • Early and precise management strategies are key to improving both short- and long-term patient outcomes.