Reactive oxygen species responsive chitooligosaccharides based nanoplatform for sonodynamic therapy in mammary cancer

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Oncology

Background:

• Sonodynamic therapy (SDT) shows promise for non-invasive mammary cancer treatment.
• Current limitations include poor water solubility and biocompatibility of sonosensitizers, hindering efficacy.
• Developing advanced nanocarriers is crucial for improving SDT performance.

Purpose of the Study:

• To engineer a multifunctional nanoplatform for enhanced sonodynamic and starvation therapy in mammary cancer.
• To improve the water solubility and biocompatibility of sonosensitizers.
• To investigate the synergistic effects of combining SDT with glucose oxidase-mediated starvation therapy.

Main Methods:

• Fabrication of a nanoplatform using host-guest interactions (β-cyclodextrin/5-(4-hydroxyphenyl)-10,15,20-triphenylporphyrin and ferrocenecarboxylic acid/chitooligosaccharides).
• Loading of glucose oxidase (GOx) via electrostatic adsorption for starvation therapy.
• Evaluation of water solubility, particle size, biocompatibility, and in vivo therapeutic efficacy in mammary cancer models.

Main Results:

• The developed nanoplatform demonstrated improved water solubility, suitable particle size, and excellent biocompatibility.
• The integrated system effectively combined sonodynamic and starvation therapy, leading to significant mammary tumor growth inhibition.
• Minimal side effects were observed in vivo, indicating a favorable safety profile.

Conclusions:

• The novel nanoplatform successfully integrates sonodynamic and starvation therapy for effective mammary cancer treatment.
• Chitooligosaccharides-based nanocarriers offer a promising strategy for developing multifunctional systems in cancer therapy.
• This approach provides new insights for optimizing SDT and combination therapy strategies.