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Cardiac Malignant Lymphoma with Diffuse Extension to the Left Ventricle

Daichi Terunuma1, Masanobu Miura1, Ko Teshima2

  • 1Department of Cardiology, Iwate Prefectural Central Hospital, Japan.

Internal Medicine (Tokyo, Japan)
|July 24, 2024
PubMed

Insights

Malignant cardiac lymphoma, a rare condition, can diffusely affect the left ventricle. Chemotherapy improved cardiac function in a patient with this heart lymphoma, demonstrating treatment efficacy.

Area of Science:

  • Cardiology
  • Oncology
  • Pathology

Background:

  • Malignant cardiac lymphoma is an uncommon diagnosis.
  • Typically presents as right-sided cardiac nodules.
  • This case highlights atypical diffuse left ventricular involvement.

Purpose of the Study:

  • To report a rare case of malignant cardiac lymphoma with diffuse left ventricular extension.
  • To describe the diagnostic findings and treatment of this condition.
  • To illustrate the potential for cardiac function improvement with chemotherapy.

Main Methods:

  • Patient presentation: Dyspnea and malaise in a woman in her 60s.
  • Diagnostic imaging: Echocardiography revealed left ventricular hypertrophy (LVH); MRI showed diffuse delayed contrast enhancement.
  • Invasive procedures: Cardiac catheterization and myocardial biopsy confirmed heart failure due to cardiac malignant lymphoma.

Main Results:

  • Diagnosis of malignant cardiac lymphoma with diffuse left ventricular infiltration.
  • Mild diastolic dysfunction observed despite significant left ventricular hypertrophy.
  • Successful treatment with chemotherapy led to improved and maintained cardiac function.

Conclusions:

  • Malignant cardiac lymphoma can present with diffuse left ventricular involvement, deviating from typical presentations.
  • Multimodality imaging and biopsy are crucial for diagnosis.
  • Chemotherapy can effectively manage cardiac lymphoma, leading to functional recovery.

Keywords:
cardiac catheterizationheart ventricleshypertrophylymphoma

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