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Anorexia and bulimia in relation to ulcerative colitis: a Mendelian randomization study
1The First Clinical Medical College of Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Frontiers in Nutrition
|July 25, 2024
Summary
Bulimia nervosa may reduce ulcerative colitis (UC) risk, while anorexia nervosa shows no causal link. Ulcerative colitis may also lower anorexia risk, suggesting complex bidirectional relationships.
Area of Science:
- Genetics
- Gastroenterology
- Psychiatry
Background:
- Limited evidence exists on the relationship between eating disorders and ulcerative colitis (UC) risk.
- This study investigates the potential causal links between anorexia nervosa, bulimia nervosa, and UC.
Purpose of the Study:
- To perform a bi-directional, two-sample Mendelian randomization (MR) analysis.
- To determine the causal association between anorexia nervosa and bulimia nervosa with UC risk.
Main Methods:
- Utilized genome-wide association studies (GWAS) data for anorexia and bulimia from UK Biobank.
- Collected genetic associations with UC from FinnGen Biobank, UK Biobank, and IIBDGC.
- Employed inverse-variance-weighted (IVW) method, MR-Egger regression, MR-PRESSO, and Cochran's Q test for analysis and validation.
Main Results:
- Genetically predicted bulimia showed a negative association with UC risk (OR=0.943, p=0.034) in the IIBDGC dataset.
- No causal association was found between genetically predicted anorexia and UC.
- Bi-directional analysis indicated UC negatively associates with anorexia risk (OR=0.877, p=0.007).
Conclusions:
- Genetically predicted bulimia may decrease the risk of developing UC.
- Genetically predicted anorexia does not appear causally linked to UC development.
- Genetically predicted UC may reduce the risk of developing anorexia.
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