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Published on: November 10, 2017
Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis
Tannaz Jamialahmadi1,2, Luis E Simental-Mendia3, Ali H Eid4
1Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Introduction:
Understanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT.
Methods:
The study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software.
Results:
In the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = -0.507, 95% CI: -2.536, 1.521, p = 0.021).
Conclusions:
Statins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.
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