Related Experiment Video
Updated: Jun 19, 2025

Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis
Published on: September 11, 2019
HIV Versus the Human Body: A Case Report of an Immunity-Compromised Patient
Ashwin Karnan1, Ulhas Jadhav2, Babaji Ghewade2
1Pulmonary Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Human immunodeficiency virus (HIV) and tuberculosis (TB) co-infection severely compromises the immune system, increasing risks. This case report highlights the significant impact of HIV-TB on patient morbidity and mortality.
Area of Science:
- Immunology
- Infectious Diseases
- Virology
Background:
- The immune system protects the body from pathogens.
- Human immunodeficiency virus (HIV) attacks immune cells, specifically CD4 T helper cells.
- HIV infection increases susceptibility to opportunistic infections like tuberculosis (TB).
Observation:
- HIV-TB co-infection presents a significant global health challenge.
- The progression to Acquired Immunodeficiency Syndrome (AIDS) is accelerated.
- There is a higher likelihood of developing drug-resistant TB.
Findings:
- HIV significantly depletes CD4 T helper cell counts.
- HIV replicates within the body, further weakening immune defenses.
- The case report details the profound effects of HIV-TB on patient health.
Implications:
- Understanding HIV-TB pathogenesis is crucial for patient management.
- Effective treatment strategies are needed to combat co-infection.
- Addressing co-infection can reduce patient morbidity and mortality.
Related Concept Videos
Sexually Transmitted Infections
Immunodeficiency Diseases
There are three main causes of immunodeficiency...
Cell-mediated Immune Responses
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Retrovirus Life Cycles
Antigens Involved in Adaptive Immunity
Complete Antigens
Complete antigens possess both immunogenicity and...

