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The Causal Association Between Obstructive Sleep Apnea and Child-Onset Asthma Come to Light: A Mendelian

Qiming Gan1, Quanzhen Liu1,2, Yanjuan Wu1

  • 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Disease, Department of Sleep Medicine Center, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, 510160, People's Republic of China.

Nature and Science of Sleep
|July 25, 2024
PubMed

Insights

Obstructive sleep apnea (OSA) causally promotes child-onset asthma and moderate-to-severe asthma, but not adult-onset asthma. These findings highlight the need for age-specific asthma management strategies.

Area of Science:

  • Respiratory Medicine
  • Genetics
  • Epidemiology

Background:

  • Observational studies suggest a link between obstructive sleep apnea (OSA) and asthma.
  • The causal relationship and impact on different asthma onset types remain unclear.

Purpose of the Study:

  • To investigate the potential causal association between OSA and asthma, including age-of-onset subtypes.
  • To provide a basis for clinical treatment strategies for OSA and asthma.

Main Methods:

  • A two-sample bi-directional Mendelian randomization (MR) analysis was conducted.
  • Data for OSA, asthma, and subtypes were sourced from FinnGen and IEU OpenGWAS.
  • Inverse-variance weighted (IVW) and sensitivity analyses, including MR-PRESSO, were employed.

Main Results:

  • Genetically predicted OSA showed a promoting effect on child-onset asthma (OR, 1.49) and moderate-to-severe asthma (OR, 1.03).
  • No significant causal association was found between OSA and adult-onset asthma.
  • A potential promoting effect of moderate-to-severe asthma on OSA was also suggested.

Conclusions:

  • OSA is causally associated with child-onset asthma and moderate-to-severe asthma.
  • The association between OSA and asthma is age-dependent, with no causal link found in adults.
  • Findings emphasize personalized, age-specific management approaches for asthma.
Abstract

Keywords:
Mendelian randomizationasthmageneticobstructive sleep apnea

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