Related Experiment Video
Updated: Jun 19, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Triglyceride Glucose Body Mass Index as 3 Year Prognostic Indicator for Major Adverse Cardiovascular and
Yan Yang1, Yong Wang2, Xiao-Yang Pei2
1Department of General Practice, The Hospital Affiliated to Inner Mongolia Minzu University, Tongliao, People's Republic of China.
Insights
The triglyceride glucose-body mass index (TyG-BMI) is an independent predictor of major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Higher TyG-BMI levels correlate with increased MACCE risk.
Area of Science:
- Cardiology
- Metabolic Syndrome
- Clinical Research
Background:
- Previous research linked triglyceride glucose-body mass index (TyG-BMI) to cardiovascular mortality in peritoneal dialysis patients.
- The predictive role of TyG-BMI in acute myocardial infarction (AMI) prognosis was previously unclear.
Purpose of the Study:
- To investigate the association between TyG-BMI and major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with AMI following percutaneous coronary intervention (PCI).
Main Methods:
- A cohort of 408 AMI patients undergoing PCI was analyzed.
- Patients were stratified into three groups based on TyG-BMI tertiles.
- Multivariate Cox regression and ROC curve analysis were employed to assess the predictive value of TyG-BMI.
Main Results:
- The incidence of MACCEs increased significantly with higher TyG-BMI tertiles (p<0.05).
- TyG-BMI was identified as an independent predictor of MACCEs in AMI patients post-PCI (p<0.05).
- The area under the ROC curve (AUC) for TyG-BMI predicting MACCEs was 0.632 (p < 0.001).
Conclusions:
- Elevated TyG-BMI levels independently predict composite MACCEs in patients with AMI after PCI.
- TyG-BMI serves as a valuable prognostic marker in this patient population.
Background:
Previous studies have suggested that triglyceride glucose-body mass index (TyG-BMI) is associated with cardiovascular mortality in patients undergoing peritoneal dialysis. However, the predictive value of TyG-BMI in the prognosis of acute myocardial infarction (AMI) remains unclear.
Methods:
In total, 408 AMI patients who underwent PCI were consecutively included in this study. All included patients were then divided into three groups according to tertiles of TyG-BMI. The association between TyG-BMI and major adverse cardiovascular and cerebrovascular events (MACCEs) were investigated.
Results:
Participants were divided into three groups: tertile 1(≤199.4, n=136), tertile 2 (199.4-231.8, n=136), and tertile 3 (≥231.8, n=136). Eighty (19.6%) patients had MACCEs: 18 (13.2%) in tertile 1, 26 (19.1%) in tertile 2, and 36 (25.7%) in tertile 3. The incidence of MACCEs increased as the tertiles of TyG-BMI increased (p<0.05). Multivariate Cox regression analysis revealed that diabetes mellitus and TyG-BMI were independent predictors of MACCEs in AMI patients after PCI (p<0.05). The receiver operating characteristic (ROC) curve showed that when TyG-BMI was ≥192.4, the sensitivity and specificity were 60.1% and 65.4%, respectively, and the area under the ROC curve (AUC) was 0.632 (95% confidence interval [CI]: 0.562-0.703; p < 0.001).
Conclusion:
Elevated TyG-BMI level was an independent predictor of the composite MACCEs in patients with AMI after PCI.
Related Concept Videos
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:24Obesity