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The prebiotic emergence of biological evolution
Charles D Kocher1,2, Ken A Dill1,2,3
1Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794, USA.
Royal Society Open Science
|July 25, 2024
Summary
Cooperative autocatalysts, which increase reproduction with population, can overcome degradation to enable evolutionary dynamics. This mechanism is demonstrated in Foldcats, peptides that catalyze each other
Area of Science:
- Origin of life studies
- Evolutionary dynamics
- Prebiotic chemistry
Background:
- Darwinian evolution requires adaptive dynamics for propagation.
- The emergence of these dynamics from prebiotic molecules remains a key question.
Purpose of the Study:
- To develop a universal framework for the origin of evolutionary dynamics.
- To identify prebiotic conditions and molecular systems capable of initiating evolution.
Main Methods:
- Evolutionary invasion analysis was employed.
- A universal framework was developed to model the transition to evolutionary dynamics.
Main Results:
- Cooperative autocatalysts, where reproduction rate increases with population, can transition from degradation to growth-dominated states.
- This transition to persistent propagation is not rare under certain conditions.
- The Foldcat Mechanism, involving self-catalyzing peptides, exhibits cooperative autocatalysis and emergent evolutionary dynamics.
Conclusions:
- Cooperative autocatalysis provides a viable pathway for the origin of evolutionary dynamics from prebiotic chemistry.
- The Foldcat Mechanism serves as a concrete example of a system capable of initiating self-propagation and evolution.
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