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Related Experiment Video

Updated: Jun 19, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Published on: November 4, 2010

Bronchial Rheoplasty for Chronic Bronchitis: Results from a Canadian Feasibility Study with RheOx^®.

Marc Fortin¹, Del R Dorscheid², Moishe Liberman³

¹Department of Pulmonary Medicine and Thoracic Surgery, University of Laval Institut Universitaire de Cardiologie et de Pneumologie de Québec (IUCPQ), Quebec City, Quebec, Canada.

International Journal of Chronic Obstructive Pulmonary Disease

|July 25, 2024

Summary

Bronchial Rheoplasty (BR) is a safe and feasible treatment for chronic bronchitis (CB), significantly improving cough and mucus symptoms. This innovative therapy shows promise for enhancing the quality of life for COPD patients.

Keywords:

COPD bronchoscopy chronic bronchitis pulsed electric fields

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Published on: April 13, 2010

Area of Science:

Pulmonology
Medical Devices
Respiratory Medicine

Background:

Chronic bronchitis (CB) is a phenotype of chronic obstructive pulmonary disease (COPD) characterized by persistent mucus hypersecretion and cough.
CB significantly impairs quality of life, increases exacerbations, and leads to lung function decline.
Bronchial Rheoplasty (BR) utilizes non-thermal pulsed electric fields to treat airway epithelium and submucosa, with prior studies indicating reduced goblet cell hyperplasia and symptom relief.

Purpose of the Study:

To evaluate the safety and clinical feasibility of Bronchial Rheoplasty (BR) in patients diagnosed with chronic bronchitis (CB).

Main Methods:

A 3-center, single-arm study enrolled Canadian patients with CB meeting specific criteria (CAT score ≥ 7 for cough/mucus, FEV1 ≥ 30% predicted).
Patients underwent BR treatment sequentially on the right and left airways, with a 1-month interval.
Safety was assessed via Serious Adverse Events (SAEs) over 12 months, while clinical outcomes were measured using the St. George's Respiratory Questionnaire (SGRQ) and COPD Assessment Test (CAT).

Main Results:

Ten CB patients (mean age 69 years) completed the 12-month follow-up, with successful BR procedures in all.
One device-related SAE (COPD exacerbation) occurred within 13 days post-procedure; no other SAEs were reported.
At 3 and 6 months, 90% of patients were CAT responders (≥ 2-point improvement), with similar positive trends observed in SGRQ scores.

Conclusions:

Bronchial Rheoplasty (BR) demonstrated a favorable safety profile and was well-tolerated by patients with chronic bronchitis.
Meaningful and sustained symptom improvement was observed up to 12 months post-treatment.
BR presents a potentially viable and effective therapeutic option for managing chronic bronchitis symptoms.