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Updated: Jun 19, 2025
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
Published on: February 9, 2019
Recent advanced lipid-based nanomedicines for overcoming cancer resistance
Piroonrat Dechbumroong1,2,3,4, Runjing Hu1,2,4, Wisawat Keaswejjareansuk3
1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100049, China.
Abstract:
The increasing prevalence of cancer drug resistance not only critically limits the efficiency of traditional therapies but also causes relapses or recurrences of cancer. Consequently, there remains an urgent need to address the intricate landscape of drug resistance beyond traditional cancer therapies. Recently, nanotechnology has played an important role in the field of various drug delivery systems for the treatment of cancer, especially therapy-resistant cancer. Among advanced nanomedicine technologies, lipid-based nanomaterials have emerged as effective drug carriers for cancer treatment, significantly improving therapeutic effects. Due to their biocompatibility, simplicity of preparation, and potential for functionalization, lipid-based nanomaterials are considered powerful competitors for resistant cancer. In this review, an overview of lipid-based nanomaterials for addressing cancer resistance is discussed. We summarize the recent progress in overcoming drug resistance in cancer by these lipid-based nanomaterials, and highlight their potential in future applications to reverse cancer resistance.
Insights
Lipid-based nanomaterials offer a promising approach to overcome cancer drug resistance, a major challenge in traditional cancer therapies. These advanced nanomedicines show potential for improved treatment outcomes in resistant cancers.
Area of Science:
- Oncology
- Nanotechnology
- Materials Science
Background:
- Cancer drug resistance limits traditional therapy efficacy and leads to recurrence.
- There is a critical need for novel strategies to combat resistant cancers.
- Nanotechnology offers advanced drug delivery systems for cancer treatment.
Purpose of the Study:
- To review the role of lipid-based nanomaterials in overcoming cancer drug resistance.
- To summarize recent advancements in using these nanomaterials for resistant cancers.
- To highlight future potential applications of lipid-based nanomaterials.
Main Methods:
- Literature review of nanotechnology applications in cancer therapy.
- Focus on lipid-based nanomaterials as drug carriers.
- Analysis of studies addressing cancer drug resistance.
Main Results:
- Lipid-based nanomaterials demonstrate significant therapeutic improvements.
- Their biocompatibility and functionalization potential make them suitable for resistant cancers.
- Recent progress shows promise in reversing cancer resistance.
Conclusions:
- Lipid-based nanomaterials are powerful tools against cancer drug resistance.
- They represent a significant advancement beyond traditional cancer therapies.
- Further research highlights their potential for future clinical applications.
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