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Related Experiment Videos

Estrogen and bone. Marshall R. Urist's contributions.

G S Gordan

    Clinical Orthopaedics and Related Research
    |November 1, 1985
    PubMed
    Summary

    Estrogen therapy effectively prevents bone loss and fractures, offering a practical prophylaxis for postmenopausal osteoporosis. This treatment is now widely accepted for managing this common geriatric disorder.

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    Area of Science:

    • Endocrinology
    • Bone Biology
    • Geriatrics

    Background:

    • Estrogens play a crucial role in maintaining bone mass.
    • Early studies noted species-specific responses to estrogens regarding bone resorption.
    • Estrogens are recognized as anticatabolic agents influencing bone metabolism.

    Purpose of the Study:

    • To review the established role of estrogens in bone mass maintenance.
    • To highlight the clinical acceptance of estrogen therapy for osteoporosis.
    • To clarify the mechanisms and clinical impact of estrogen's anti-resorptive effects.

    Main Methods:

    • Review of kinetic and radiographic studies quantifying estrogen's anticatabolic effects.
    • Analysis of epidemiological and morphometric data on fracture prevention.
    • Examination of in vitro and in vivo studies on estrogen receptor presence and action mediation.

    Main Results:

    • Estrogens inhibit endosteal resorption and reduce osteoclast numbers.
    • Estrogen therapy is clinically accepted for osteoporosis prevention and treatment.
    • Fracture prevention by estrogen is morphometrically and epidemiologically established.
    • Estrogen's antiosteolytic action is mediated by calcitonin, as bone lacks direct estrogen receptors.

    Conclusions:

    • Estrogen therapy provides effective and safe prophylaxis for postmenopausal osteoporosis.
    • This addresses a significant public health issue, reducing fractures, deformity, and mortality.
    • Estrogen's role in bone health management is well-supported by extensive research.

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