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Updated: Jun 19, 2025
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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
Published on: January 7, 2019
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Oncogenic Roles of UHRF1 in Cancer
Ahhyun Kim1, Claudia A Benavente1,2,3
1Department of Pharmaceutical Sciences, University of California, Irvine, CA 92697, USA.
Epigenomes
|July 25, 2024
Summary
Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) maintains epigenetic stability but is overexpressed in cancers. This review explores UHRF1
Area of Science:
- Epigenetics and Cancer Biology
Background:
- Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is crucial for maintaining epigenetic marks and stability.
- UHRF1 is implicated in DNA methylation, histone modification, and DNA repair through its functional domains.
- The RB/E2F pathway, frequently deregulated in cancer, controls UHRF1 levels, which are normally cell cycle-dependent and regulated by proteasomal degradation.
Purpose of the Study:
- To review the functional domains of UHRF1.
- To highlight UHRF1's interacting proteins and oncogenic roles in solid tumors.
- To explore therapeutic strategies targeting UHRF1 for potential clinical applications.
Main Methods:
- Literature review focusing on UHRF1's structure, function, and role in cancer.
- Analysis of UHRF1's involvement in epigenetic maintenance and its deregulation in oncogenesis.
- Examination of current and potential therapeutic interventions targeting UHRF1.
Main Results:
- UHRF1 is overexpressed in various cancers, acting as an oncogenic driver.
- Key solid tumors discussed include retinoblastoma, osteosarcoma, lung cancer, and breast cancer.
- UHRF1's functional domains and protein interactions are central to its oncogenic activity.
Conclusions:
- UHRF1 is a significant oncogenic driver in multiple solid tumors due to its overexpression and role in epigenetic dysregulation.
- Targeting UHRF1 domains or its interacting proteins presents promising therapeutic avenues.
- Further research into UHRF1-targeted therapies could lead to novel clinical applications in oncology.
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