Digital Papillary Adenocarcinoma: The Detection of Low-Risk Human Papillomaviruses and the BRAF p.V600E Mutation in a Subset of Cases
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View abstract on PubMed
Summary
This summary is machine-generated.Digital papillary adenocarcinoma (DPA) is a rare skin cancer. This study found a stronger association between DPA and low-risk human papillomavirus (LR-HPV) than BRAF mutations, aiding diagnosis.
Area Of Science
- Dermatopathology
- Oncology
- Virology
Background
- Digital papillary adenocarcinoma (DPA) is a rare sweat gland neoplasm with metastatic potential.
- DPA presents diagnostic challenges due to varied architectural and grade features, often mimicking benign neoplasms like acral hidradenoma.
- Recent literature suggests associations between DPA and human papillomavirus (HPV) 42 and BRAF p.V600E.
Purpose Of The Study
- To evaluate the diagnostic utility of in situ hybridization (ISH) for low-risk HPV (LR-HPV) and immunohistochemistry (IHC) for BRAF p.V600E.
- To differentiate DPA from acral hidradenoma using these molecular markers.
Main Methods
- Retrospective analysis of 15 DPA and 3 acral hidradenoma specimens.
- ISH for LR-HPV (types 6, 11, 40, 42, 43, 44) and IHC for BRAF p.V600E were performed.
Main Results
- Of 13 DPA cases, 6 were negative for both markers, 6 were positive for LR-HPV only, and 1 was positive for BRAF p.V600E only.
- All 3 acral hidradenoma cases were negative for both LR-HPV and BRAF p.V600E.
- A stronger association was observed between DPA and LR-HPV compared to BRAF p.V600E.
Conclusions
- LR-HPV detection shows a stronger association with DPA than BRAF p.V600E.
- These markers may aid in distinguishing DPA from acral hidradenoma.
- Larger studies are needed to confirm the diagnostic value of LR-HPV and BRAF p.V600E in DPA.
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