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Published on: December 7, 2012
Treatment of Immune Thrombocytopenia: Contextualization from a Historical Perspective
Daniel Martínez-Carballeira1,2, Ángel Bernardo1,2, Alberto Caro1,2
1Department of Hematology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.
Abstract:
Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated decrease in platelet count and an increased risk of bleeding. The pathogenesis is complex, affecting multiple components of the immune system and causing both peripheral destruction of platelets and inadequate production in the bone marrow. In this article, we review the treatment of ITP from a historical perspective, discussing first line and second line treatments, and management of refractory disease.
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