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Association Between Handgrip Strength and Mortality of Patients With Coronary Artery Disease: A Meta-Analysis

Meiling Xiao1, Yu Lu2, Hongqiu Li1

  • 1Department of Rehabilitation, Central Hospital Affiliated to Shenyang Medical College, Shenyang, China.

Clinical Cardiology
|July 25, 2024
PubMed

Insights

Weak handgrip strength (HGS) in coronary artery disease (CAD) patients indicates a higher risk of death. This risk is especially pronounced in older individuals with CAD, highlighting HGS as a critical health indicator.

Area of Science:

  • Cardiology
  • Public Health
  • Geriatrics

Background:

  • Muscular strength is a known factor influencing cardiovascular disease risk in the general population.
  • Handgrip strength (HGS) is a readily measurable indicator of overall muscular strength.
  • The relationship between HGS and mortality in patients with established coronary artery disease (CAD) requires further elucidation.

Purpose of the Study:

  • To systematically review and meta-analyze observational studies.
  • To evaluate the association between low handgrip strength (HGS) and mortality risk in patients diagnosed with coronary artery disease (CAD).

Main Methods:

  • An extensive literature search was performed across multiple major scientific databases (PubMed, Embase, Web of Science, Cochrane Library, Wanfang, CNKI).
  • Observational studies with longitudinal follow-up data were included.
  • Random-effects models were employed to synthesize findings and account for study heterogeneity.

Main Results:

  • Eight studies comprising 10,543 CAD patients were analyzed.
  • A mean follow-up of 20.4 months revealed 1327 (12.6%) deaths.
  • Low baseline HGS was significantly associated with increased all-cause mortality risk (RR: 1.95, 95% CI: 1.50-2.55).
  • A stronger association was observed in older CAD patients (RR: 3.01) compared to the overall cohort (RR: 1.60).

Conclusions:

  • Baseline handgrip strength is a significant predictor of mortality in patients with coronary artery disease.
  • Older patients with CAD and low HGS face a particularly elevated mortality risk.
  • HGS serves as a valuable prognostic marker in the management of CAD patients.
Abstract

Keywords:
coronary artery diseasehandgrip strengthmeta‐analysismortalityrisk factor

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