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Fabrication and Design of Wood-Based High-Performance Composites
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Engineering High-Performance Composite Cellulose Materials for Fast Hemostasis.

Binshou Wang1,2, Xue Li1, Luyao Wei1,2

  • 1Center of Biomass Engineering/College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.

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|July 25, 2024
PubMed
Summary

A novel cellulosic aerogel was developed for rapid hemostasis, offering a cost-effective and scalable solution for uncontrolled hemorrhage. This advanced material demonstrates superior absorption and blood coagulation properties for emergency wound care.

Keywords:
biomassbiomaterialscellulosehemostatic agentpretreatment

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Area of Science:

  • Biomaterials Engineering
  • Materials Science
  • Medical Device Development

Background:

  • Uncontrolled hemorrhage is a leading cause of preventable death following traumatic injury.
  • Current hemostatic agents often present challenges with complex preparation and limited biocompatibility.
  • There is a critical need for efficient, easy-to-prepare, and biocompatible hemostatic materials.

Purpose of the Study:

  • To engineer a cellulosic-derived aerogel for rapid hemostasis.
  • To investigate the impact of freeze-drying pretreatments on aerogel properties and hemostatic performance.
  • To elucidate the structure-function relationship and mechanism of fast hemostasis.

Main Methods:

  • Cellulose regeneration and controlled drying processes were employed to create aerogel materials.
  • Four different freeze-drying pretreatments were evaluated.
  • Material characterization included XRD, FTIR, X-ray CT, SEM, and zeta potential analysis.
  • In vitro blood coagulation tests were performed to assess hemostatic efficacy.

Main Results:

  • The cellulosic aerogel prepared without freezing pretreatment exhibited the lowest crystallinity (21.3%) and highest fluid absorption (20.3x its weight).
  • This optimized aerogel demonstrated excellent in vitro hemostasis, achieving blood coagulation in approximately 100 seconds.
  • Addition of gelatin and diatomite further enhanced hemostatic performance by tuning functional groups and electrostatic properties.
  • Characterization confirmed a super hierarchical porous structure responsible for the high absorption capacity.

Conclusions:

  • A cost-effective and scalable cellulosic aerogel with superior hemostatic capabilities was successfully developed.
  • The material's hierarchical porous structure and tunable properties facilitate rapid hemostasis.
  • This aerogel represents a promising candidate for practical application in managing severe bleeding incidents.