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Related Experiment Videos

Disturbances of puberty.

R Stanhope, J Adams, C G Brook

    Clinics in Obstetrics and Gynaecology
    |September 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Puberty progression relies on pulsatile gonadotropin-releasing hormone (GnRH) and gonadotropins. Understanding GnRH pulse abnormalities aids diagnosis and treatment of delayed or precocious puberty.

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    Area of Science:

    • Reproductive Endocrinology
    • Pediatric Endocrinology
    • Neuroendocrinology

    Background:

    • Puberty initiation and progression depend on pulsatile stimulation of the pituitary by GnRH and gonads by LH and FSH.
    • Gonadal maturation is a continuous process throughout childhood, not solely confined to puberty.
    • Consonance in acquiring sexual maturation components, including growth acceleration, signifies normal development; deviations indicate abnormality.

    Purpose of the Study:

    • To differentiate constitutional delay of growth and puberty from gonadotropin deficiency.
    • To explore treatment options for both conditions.
    • To highlight the significance of pulsatile gonadotropin secretion in normal and abnormal puberty.

    Main Methods:

    • Discussion of normal puberty events and sexual maturation.

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  • Analysis of methods to distinguish constitutional delay from gonadotropin deficiency.
  • Assessment of gonadotropin pulsatility, including non-invasive ultrasound evaluation of ovarian morphology in girls.

    • Main Results:

    • Pulsatile GnRH therapy effectively mimics normal puberty.
    • GnRH analogue therapy can suppress central precocious puberty by abolishing gonadotropin pulsatility.
    • Qualitative pulse abnormalities in gonadotropin secretion are recognized in isolated premature thelarche and some delayed puberty cases.

    Conclusions:

    • Clinical assessment is crucial for diagnosing puberty disorders.
    • Studies on gonadotropin pulsatility have advanced the understanding and treatment of these conditions.
    • Multicystic ovarian morphology on ultrasound serves as a non-invasive marker for gonadotropin pulsatility in girls.