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Related Experiment Video

Updated: Jun 19, 2025

Ex Situ Normothermic Machine Perfusion of Donor Livers
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[Machine perfusion in transplantation surgery].

Felicia Kneifel1, Florian Vondran2, Thomas Vogel3

  • 1Klinik für Allgemein‑, Viszeral- und Transplantationschirurgie, Universitätsklinikum Münster, Münster, Deutschland.

Chirurgie (Heidelberg, Germany)
|July 25, 2024
PubMed
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Machine perfusion significantly improves donor organ preservation compared to static cold storage, offering a promising solution to organ shortages. This technology also allows for pre-transplant organ quality assessment, potentially expanding the donor pool.

Area of Science:

  • Transplantation Medicine
  • Medical Devices
  • Organ Preservation Technologies

Background:

  • Machine perfusion is increasingly utilized in solid organ transplantation globally.
  • While randomized controlled trials are limited, machine perfusion demonstrates superiority over static cold storage for donor organs.
  • Current research focuses on optimizing perfusion strategies and evaluating synergistic effects of sequential protocols.

Purpose of the Study:

  • To optimize organ preservation between donor organ removal and transplantation.
  • To assess the quality of marginal donor organs before transplantation, reducing patient risk.
  • To expand the donor pool, addressing organ shortages and restrictive legislation.

Main Methods:

  • Utilizing hypothermic or normothermic machine perfusion devices for various organs.
Keywords:
Hypothermic machine perfusionNormothermic machine perfusionOrgan conservationOrgan transplantationViability testing

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  • Investigating different perfusion strategies and their comparative efficacy.
  • Exploring sequential use of perfusion protocols for potential synergistic effects.

    • Main Results:

    • Machine perfusion is superior to static cold storage for donor organ preservation.
    • Various clinical devices are available for hypothermic and normothermic perfusion.
    • Potential for pre-transplant assessment of marginal donor organs to expand the donor pool.

    Conclusions:

    • Machine perfusion optimizes organ preservation and offers a platform for ex situ/in situ therapies.
    • It enables the use of marginal donor organs, expanding the donor pool and addressing shortages.
    • Future applications include conditioning pre-damaged organs and improving transplant logistics.