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Related Experiment Video

Updated: Jun 19, 2025

A Patient-Derived Xenograft Model for Venous Malformation
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Infantile hemangiomas: a dermatologist's perspective.

Apoorva Sharma1, Manavi Gupta1, Rahul Mahajan2

  • 1Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

European Journal of Pediatrics
|July 25, 2024
PubMed
Summary
This summary is machine-generated.

Infantile hemangioma (IH), a common pediatric vascular tumor, arises from stem cell issues. This review covers IH causes, symptoms, and treatments, stressing a team approach for better outcomes.

Keywords:
DermatologyInfantile hemangiomaPediatric

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Area of Science:

  • Pediatric Oncology
  • Vascular Biology
  • Dermatology

Background:

  • Infantile hemangioma (IH) is the most common pediatric vascular tumor.
  • IH pathogenesis is linked to stem cell anomalies, hypoxia, and the renin-angiotensin system.
  • Risk factors include prematurity, low birth weight, and family history.

Purpose of the Study:

  • To provide a comprehensive review of infantile hemangioma.
  • To discuss the epidemiology, pathogenesis, clinical features, and complications of IH.
  • To detail diagnostic modalities and management strategies for IH.

Main Methods:

  • Literature review of infantile hemangioma.
  • Analysis of epidemiological data and risk factors.
  • Examination of pathogenetic mechanisms and clinical manifestations.

Main Results:

  • IH involves complex stem cell responses and molecular pathways.
  • Extracutaneous involvements like hepatic IH, PHACES, and LUMBAR syndromes are significant.
  • Complications include ulceration, functional impairment, hypothyroidism, and cosmetic issues.

Conclusions:

  • A multidisciplinary approach is crucial for managing infantile hemangioma.
  • Current management includes propranolol, atenolol, corticosteroids, and other therapies.
  • Ongoing research focuses on novel treatments and individualized IH management.