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Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Pulmonary Tuberculosis I01:29

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
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The JAK-STAT Signaling Pathway01:20

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognostic Factors For Interstitial Lung Disease Progression In Rheumatoid Arthritis: May Methotrexate Protect Against Progression?
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Prognostic Factors For Interstitial Lung Disease Progression In Rheumatoid Arthritis: May Methotrexate Protect Against Progression?

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Prognostic factors for interstitial lung disease progression in rheumatoid arthritis: May methotrexate protect against progression?

M Ekici1, Y Baytar2, A Akdoğan1

  • 1Department of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Scandinavian Journal of Rheumatology
|July 25, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Methotrexate use was linked to slower interstitial lung disease (ILD) progression in rheumatoid arthritis (RA) patients. This finding suggests a protective effect of methotrexate in RA-ILD, warranting further investigation.

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Area of Science:

  • Rheumatology
  • Pulmonology
  • Radiology

Background:

  • Rheumatoid arthritis (RA) can lead to interstitial lung disease (ILD), a significant cause of morbidity and mortality.
  • Lung computed tomography (CT) is crucial for detecting and monitoring RA-associated ILD (RA-ILD) progression.
  • Identifying factors associated with RA-ILD progression is essential for patient management.

Purpose of the Study:

  • To compare characteristics of RA-ILD patients with and without radiographic progression using lung CT.
  • To identify risk factors for and protective elements against RA-ILD progression.

Main Methods:

  • Retrospective observational study analyzing lung CT scans from 104 RA-ILD patients.
  • Radiographic progression defined by increased zone involvement or worsening findings on serial CT scans.
  • Logistic regression analysis to determine factors associated with progression.

    • Main Results:

    • Radiographic progression was observed in 41.3% of patients.
    • Male sex, positive chest X-ray findings for ILD, age over 50 at ILD diagnosis, and ground-glass opacity on CT were associated with progression.
    • Male sex and positive chest X-ray findings were independent risk factors; methotrexate use was an independent protective factor.

    Conclusions:

    • Methotrexate use demonstrated a negative association with ILD progression in RA patients.
    • Further studies are needed to confirm the protective role of methotrexate in RA-ILD.