Biodegradable Plant Oil-Based Bioadhesive with Ultrastrong Wet-Tissue Adhesion for Instant Sealing Hemostasis

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Medical Devices

Background:

• Effective hemostasis is critical for emergency bleeding management.
• Current hemostatic agents have limitations in achieving rapid and robust sealing.

Purpose of the Study:

• To develop a plant oil-based bioadhesive for instant and effective hemostasis.
• To evaluate the performance, biocompatibility, and hemostatic ability of the EMTA/Zn²⁺ bioadhesive.

Main Methods:

• Facile synthesis of EMTA/Zn²⁺ bioadhesive from epoxidized soybean oil, methacrylic acid, and tannic acid with zinc ion coordination.
• In situ photo-cross-linking using UV LED irradiation within 30 seconds.
• Assessment of wet-tissue adhesion, in vitro burst pressure, hemocompatibility, biodegradability, cytocompatibility, antibacterial properties, and in vivo hemostatic efficacy.

Main Results:

• Rapid UV curing achieved within 30 seconds.
• Ultrong wet-tissue adhesion (92.4 kPa to porcine skin, 51.8 kPa to aortic skin after 7 days underwater).
• High in vitro burst pressure (525 mmHg to porcine skin, 337.5 mmHg to aortic skin).
• Excellent hemocompatibility, biodegradability, cytocompatibility, and antibacterial properties.
• Remarkable in vivo hemostatic ability in liver bleeding models.

Conclusions:

• The plant oil-based EMTA/Zn²⁺ bioadhesive demonstrates superior adhesion and sealing performance.
• It possesses favorable biocompatibility and antibacterial properties.
• This bioadhesive presents a promising alternative for clinical applications requiring instant hemostasis, particularly for internal organ and arterial bleeding.