Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigenic variability of Candida albicans.

D Poulain, V Hopwood, A Vernes

    Critical Reviews in Microbiology
    |January 1, 1985
    PubMed
    Summary

    Candida albicans, a yeast, exhibits antigenic variations linked to its pathogenic behavior. Further research is needed to understand the mechanisms behind these dynamic antigenic changes in this opportunistic pathogen.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Uric acid levels are independent of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease: A reappraisal of the role of S. cerevisiae in this setting.

    Virulence·2018
    Same author

    Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn's Disease.

    mBio·2016
    Same author

    The Cek1‑mediated MAP kinase pathway regulates exposure of α‑1,2 and β‑1,2‑mannosides in the cell wall of Candida albicans modulating immune recognition.

    Virulence·2016
    Same author

    Role of mannose-binding lectin in intestinal homeostasis and fungal elimination.

    Mucosal immunology·2015
    Same author

    Initiation of phospholipomannan β-1,2 mannosylation involves Bmts with redundant activity, influences its cell wall location and regulates β-glucans homeostasis but is dispensable for Candida albicans systemic infection.

    Biochimie·2015
    Same author

    Applicability of Macroscopic Wear and Friction Laws on the Atomic Length Scale.

    Physical review letters·2015

    Area of Science:

    • Microbiology
    • Immunology
    • Molecular Biology

    Background:

    • Modern biology posits that all structures undergo continuous change.
    • Ultrastructural and biochemical methods confirm dynamic changes in Candida albicans.
    • Candida albicans is an opportunistic yeast with significant clinical relevance.

    Purpose of the Study:

    • To analyze antigens as a method for studying antigenic variations in Candida albicans.
    • To address the paradoxical scarcity of research on antigenic variability and its mechanisms in Candida albicans, despite available data on its somatic and metabolic antigens.
    • To investigate the potential link between specific antigen expression and the pathogenic behavior of Candida albicans.

    Main Methods:

    • Broad analysis of antigens.
    • Ultrastructural methods.
    • Biochemical methods.

    Main Results:

    • Antigenic variations in Candida albicans have been objectified using ultrastructural and biochemical methods.
    • Despite extensive information on somatic and metabolic antigens, few studies have investigated antigenic variability and its underlying mechanisms.
    • Preliminary findings suggest a potential correlation between the expression of particular antigens and the yeast's behavior, especially during pathogenesis.

    Conclusions:

    • Antigenic variability is a characteristic of Candida albicans that warrants further investigation.
    • Understanding the mechanisms of antigenic variation may provide insights into the pathogenesis of Candida albicans infections.
    • Linking specific antigen expression to pathogenic behavior could inform future therapeutic strategies.

    Related Experiment Videos