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Published on: January 4, 2017
Total Synthesis of Conjugation-Ready Hyperbranched Pentasaccharide of Clavibacter phaseoli VKM Ac-2641T by [Au]/[Ag]
Pratim Kumar Das1, Srinivas Hotha1
1Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411 008, India.
Abstract:
Infections by Clavibacter spp. cause an economic burden to farmers. The components present in the cell wall glycopolymers (CWGs) are important for studying the host-pathogen interactions, colonization, and infection. A pentasaccharide containing a hyperbranched Ribf-, Galf-, and Manp- has recently been identified. Herein, we describe the first total synthesis of the conjugation-ready hyperbranched pentasaccharide of C. phaseoli VKM Ac-2641T using the [Au]/[Ag]-catalyzed glycosidation chemistry of ethynylcyclohexyl carbonate glycosyl donors. The pentasaccharide was synthesized in a highly convergent fashion from readily accessible monosaccharide building blocks.
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