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Chassis-based fiber-coupled optical probe design for reproducible quantitative diffuse optical spectroscopy

Giselle C Matlis1,2, Qihuang Zhang3,4, Emilie J Benson1,5

  • 1Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, United States of America.

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A new chassis-based optical probe for diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) offers accurate and reproducible neuromonitoring of cerebral hemodynamics. This innovation simplifies probe application in critical care settings.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Medical Devices

Background:

  • Non-invasive neuromonitoring of cerebral hemodynamics is crucial for critically ill patients.
  • Current diffuse optical spectroscopy (DOS) and diffuse correlation spectroscopy (DCS) probes face challenges in rapid, reproducible clinical application.
  • Existing fiber-coupled probes are difficult to apply quickly in emergent situations.

Purpose of the Study:

  • To develop and validate a novel chassis-based optical probe for DOS/DCS measurements.
  • To assess the accuracy and reproducibility of the chassis-based probe compared to manual methods.
  • To improve the clinical utility of optical neuromonitoring in critical care.

Main Methods:

  • A novel chassis-based optical probe design with a detachable fiber housing and a 3D-printed chassis was developed.
  • Cerebral hemodynamics (blood flow index, oxygen saturation, hemoglobin concentrations) were measured in pediatric swine (n=20).
  • Measurements were compared between the chassis-based probe and manually held probes for accuracy and reproducibility (coefficient of variation).

Main Results:

  • The chassis-based probe demonstrated comparable accuracy and reproducibility to manual measurements.
  • No significant differences in absolute values or coefficient of variation (CV) were found between methods (p > 0.05).
  • Blood flow index (BFI) showed significantly higher CV than oxygen saturation (StO2) regardless of probe application method (p<0.001).

Conclusions:

  • The chassis-based DOS/DCS probe design enables rapid and reproducible attachment for neuromonitoring.
  • This novel design offers a viable alternative to conventional manual probe alignment.
  • The chassis-based probe has potential for clinical adaptation in pediatric critical care for non-invasive brain health monitoring.