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Desensitization with human (recombinant DNA) insulin.

T W Bodendorfer, M E Brown, E H Frankel

    Drug Intelligence & Clinical Pharmacy
    |November 1, 1985
    PubMed
    Summary
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    A patient with gestational diabetes experienced an insulin allergy. A novel desensitization protocol using human insulin successfully treated the allergy, enabling continued insulin therapy.

    Area of Science:

    • Endocrinology
    • Allergology
    • Immunology

    Background:

    • Gestational diabetes mellitus (GDM) requires insulin therapy in some cases.
    • Insulin allergy is a rare but significant complication of insulin treatment.
    • Standard desensitization protocols may not be effective for all patients.

    Observation:

    • A 34-year-old woman with GDM developed an allergy to beef-pork and beef insulin.
    • Initial desensitization attempts with a commercial purified pork insulin kit failed.
    • The patient exhibited reactivity to human insulin, elevated IgE, and eosinophilia.

    Findings:

    • A novel desensitization protocol using human (recombinant DNA) insulin was developed and implemented.
    • This second desensitization attempt was successful in resolving the insulin allergy.

    Related Experiment Videos

  • The patient could tolerate human insulin after the specialized desensitization procedure.

    • Implications:

    • This case highlights the potential for successful desensitization in patients with complex insulin allergies.
    • A tailored human insulin desensitization protocol offers a viable alternative when standard methods fail.
    • Further research into individualized insulin desensitization strategies is warranted for allergic patients.