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Related Experiment Video

Updated: Jun 19, 2025

Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells

Rapid Antibody Glycoengineering in Chinese Hamster Ovary Cells

Published on: June 2, 2022

Glycoengineering in antigen-specific immunotherapies.

Yuxin Li¹, Hongming Chen¹, Jiuxiang Gao¹

¹State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China.

Current Opinion in Chemical Biology

|July 25, 2024

Summary

This summary is machine-generated.

Glycoengineering offers new ways to improve immunotherapies by targeting disease-associated glycans, creating novel glycoimmune checkpoints for better cancer treatments.

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Area of Science:

Immunology
Biotechnology
Glycoscience

Background:

Current immunotherapies targeting protein antigens have limited efficacy for many patients.
New glycoimmune checkpoints, distinct from protein-based ones, offer alternative therapeutic targets.
Glycoengineering holds promise for enhancing biopharmaceuticals and developing novel therapies.

Purpose of the Study:

To review recent advancements in glycoengineering of antibodies and cells for therapeutic applications.
To highlight living-cell glycoengineering strategies for improved cancer and immune cell therapies.
To discuss the role of glycoengineering in immuno-oncology research and antigen-specific immunotherapies.

Main Methods:

Review of recent literature on glycoengineering techniques (chemical, enzymatic, genetic).
Analysis of glycoengineering applications in antibody and cell-based therapies.
Exploration of living-cell glycoengineering strategies for cancer and immune cells.

Main Results:

Glycoengineering enables tailoring therapies with antigen-targeting agents.
Living-cell glycoengineering enhances therapeutic efficacy against specific antigens.
Glycoengineering strategies are valuable tools for studying immuno-oncology.

Conclusions:

Glycoengineering is crucial for designing effective antigen-specific immunotherapies.
Targeting disease-associated glycans via glycoengineering presents a promising therapeutic avenue.
This approach offers orthogonal mechanisms to existing protein-based immunotherapies.