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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

352
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
352
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  11. Public Attitudes To Xenotransplantation: A National Survey In The United States

Public attitudes to xenotransplantation: A national survey in the United States

Luz A Padilla1, Daniel J Hurst2, Amanda Zink3

  • 1Department of Surgery, Division of Cardiothoracic Surgery, The University of Alabama at Birmingham, Alabama, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|July 25, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Public acceptance of xenotransplantation (XTx) is crucial for clinical trials. While some are open to receiving pig organs, concerns about safety and knowledge gaps persist, especially among younger, female, and minority populations.

Area of Science:

  • Medical Ethics
  • Transplantation Science
  • Public Health

Background:

  • Organ transplantation faces a critical shortage of donor organs.
  • Xenotransplantation (XTx), using animal organs, offers a potential solution.
  • Public perception is vital for the future clinical application of XTx.

Purpose of the Study:

  • To explore barriers to public acceptance of xenotransplantation in the U.S.
  • To identify demographic characteristics associated with attitudes toward XTx.
  • To gauge public knowledge and concerns regarding organ transplantation and XTx.

Main Methods:

  • A national survey of 5008 U.S. adults (≥18 years) was conducted.
  • The survey assessed demographic factors, knowledge of transplantation/XTx, and attitudes toward XTx.
Keywords:
United Statesattitudessurveyxenotransplantation

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Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model
07:34

Quantification of Circulating Pig-Specific DNA in the Blood of a Xenotransplantation Model

Published on: September 22, 2020

4.0K
Xenotransplantation of Human Stem Cells into the Chicken Embryo
15:42

Xenotransplantation of Human Stem Cells into the Chicken Embryo

Published on: July 11, 2010

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Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
05:10

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  • Regression analysis identified characteristics linked to acceptance of XTx.

    • Main Results:

    • Half of respondents had low knowledge of transplantation or XTx.
    • 40% expressed discomfort with receiving a pig organ.
    • 36% were open to experimental XTx, but 57% cited concerns about safety and evidence.

    Conclusions:

    • Public acceptance of xenotransplantation is moderate but faces significant barriers.
    • Younger individuals, females, and minority groups showed lower acceptance rates.
    • Addressing knowledge gaps and safety concerns is essential for advancing XTx.