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Related Experiment Videos

Physiological variations of normal transit time in children.

G Vivian, T M Barratt, A Todd-Pokropek

    European Journal of Nuclear Medicine
    |January 1, 1985
    PubMed
    Summary

    Hydration significantly impacts kidney transit time analysis using 99mTc-diethylenetriaminepentaacetic Acid (DTPA) scans. Hypotonic volume expansion shortens whole kidney mean transit time (MTT), primarily affecting pelvic clearance.

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    Area of Science:

    • Nuclear Medicine
    • Renal Physiology
    • Pediatric Nephrology

    Background:

    • 99mTc-diethylenetriaminepentaacetic Acid (DTPA) scans quantify individual kidney glomerular filtration rate (IKGFR) and mean transit time (MTT).
    • Kidney MTT is influenced by renal parenchymal MTT and pelvic clearance, both affected by hydration status.

    Purpose of the Study:

    • To investigate the impact of physiological hydration variations on normal DTPA scan parameters.
    • To assess the influence of hypotonic volume expansion (HVE) on kidney MTT and IKGFR.

    Main Methods:

    • Studied contralateral normal kidneys in 11 children with suspected unilateral urinary tract obstruction.
    • Performed early morning scans (EMS) and repeated scans 24 hours later after HVE.
    • Analyzed urine osmolality, IKGFR, and MTT (whole kidney, parenchymal, and pelvic clearance).

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    Main Results:

    • A strong correlation was observed between urine osmolality and MTT.
    • IKGFR remained independent of hydration state.
    • HVE significantly shortened whole kidney MTT (P < 0.001) and parenchymal MTT (P < 0.01) compared to mild hydration, predominantly affecting pelvic clearance.

    Conclusions:

    • Caution is advised when interpreting whole kidney MTT without standardizing hydration.
    • Parenchymal transit time appears to be a more stable clinical index, less affected by hydration changes.
    • Hydration status significantly influences DTPA scan-derived whole kidney MTT, primarily via changes in pelvic clearance.