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Updated: May 25, 2026

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

BASEHIT scores home run: elucidates pathogen-host interactions.

Kelly A Brayton¹, Jason M Park¹

¹Program in Vector-Borne Disease, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, USA.

Trends in Parasitology

|July 25, 2024

Summary

Researchers identified 1303 potential interactions between human proteins and pathogens using bacterial selection to elucidate host-microbe interactions in high throughput (BASEHIT). This high-throughput screening advances understanding of host-microbe relationships.

Keywords:

exoproteins vector-borne yeast display

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Area of Science:

Microbiology
Genomics
Biotechnology

Background:

Understanding host-microbe interactions is crucial for disease research.
High-throughput screening methods are needed to analyze complex biological systems.

Purpose of the Study:

To identify novel interactions between human exoproteins and pathogens.
To leverage a high-throughput screening technique for interaction discovery.

Main Methods:

Utilized bacterial selection to elucidate host-microbe interactions in high throughput (BASEHIT).
Screened a yeast display library of 3324 human exoproteins against 82 pathogen samples.
Focused on vector-borne pathogens to identify specific interactions.

Main Results:

Identified 1303 putative interactions between human exoproteins and pathogens.
Demonstrated the efficacy of BASEHIT for large-scale interaction screening.
Provided a valuable dataset for further research into host-pathogen dynamics.

Conclusions:

The BASEHIT technique is effective for discovering host-microbe interactions.
The identified interactions offer new targets for understanding and combating infectious diseases.
This study expands the known landscape of human-pathogen interactions.