Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.8K
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

1.5K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
1.5K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K
Proteoglycans01:05

Proteoglycans

3.9K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Categorization of Tinnitus Severity for the Mandarin Tinnitus Questionnaire.

Ear, nose, & throat journal·2019
Same author

Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1.

Cell reports·2019
Same author

The structure-based traceless specific fluorescence labeling of the smoothened receptor.

Organic & biomolecular chemistry·2019
Same author

Expressions of melanoma-associated antigen A1 as a prognostic factor in Chinese patients with resectable oesophageal squamous cell carcinoma.

Interactive cardiovascular and thoracic surgery·2019
Same author

Transcriptomic analysis reveals the mechanism on the response of Chlorococcum sp. GD to glucose concentration in mixotrophic cultivation.

Bioresource technology·2019
Same author

Proteomics analysis of HSV-1-induced alterations in mouse brain microvascular endothelial cells.

Journal of neurovirology·2019

Related Experiment Video

Updated: Jun 19, 2025

Intravitreal Injections in the Ovine Eye
03:37

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

3.2K

Lactate/lactylation in ocular development and diseases.

Peiwei Chai1, Fei Zhao2, Renbing Jia1

  • 1Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, 200011, People's Republic of China.

Trends in Molecular Medicine
|July 25, 2024
PubMed
Summary
This summary is machine-generated.

Lactylation, a key process regulated by lactate, influences gene activity and cell energy. This study explores its vital role in eye development, retinal health, and diseases like myopia and cancer.

More Related Videos

Manipulating the Murine Lacrimal Gland
05:56

Manipulating the Murine Lacrimal Gland

Published on: November 18, 2014

20.8K
Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids
10:49

Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids

Published on: February 3, 2023

2.8K

Related Experiment Videos

Last Updated: Jun 19, 2025

Intravitreal Injections in the Ovine Eye
03:37

Intravitreal Injections in the Ovine Eye

Published on: July 5, 2022

3.2K
Manipulating the Murine Lacrimal Gland
05:56

Manipulating the Murine Lacrimal Gland

Published on: November 18, 2014

20.8K
Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids
10:49

Establishment, Maintenance, Differentiation, Genetic Manipulation, and Transplantation of Mouse and Human Lacrimal Gland Organoids

Published on: February 3, 2023

2.8K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Ophthalmology

Background:

  • Lactylation is a post-translational modification (PTM) triggered by lactate.
  • Lactylation impacts critical cellular processes including transcription, DNA repair, and mitochondrial metabolism.

Purpose of the Study:

  • To investigate the function of lactate/lactylation signaling in eye development and retinal homeostasis.
  • To examine the involvement of lactylation in ophthalmic disorders such as myopia, intraocular tumors, and retinal blood vessel growth.

Main Methods:

  • Review of existing literature on lactylation and ocular biology.
  • Analysis of molecular pathways involved in lactate signaling in the eye.
  • Correlation of lactylation markers with ophthalmic disease phenotypes.

Main Results:

  • Lactylation plays a significant role in regulating eye morphogenesis.
  • Lactate/lactylation signaling is crucial for maintaining retinal homeostasis.
  • Aberrant lactylation is implicated in the pathogenesis of myopia, intraocular malignancies, and retinal angiogenesis.

Conclusions:

  • Lactate/lactylation signaling is a critical regulator of ocular development and function.
  • Targeting lactylation pathways may offer novel therapeutic strategies for various eye diseases.
  • Further research into lactylation's role in ophthalmology is warranted.