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High Lumbar Spinal Fusion Rates Using Cellular Bone Allograft Irrespective of Surgical Approach.

Todd Lansford1, Daniel K Park2, Joshua J Wind3

  • 1South Carolina Sports Medicine, North Charleston, SC, USA tlansford@gmail.com.

International Journal of Spine Surgery
|July 25, 2024
PubMed
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Cellular bone allograft (CBA) demonstrates high spinal fusion success rates across anterior, lateral, and posterior approaches. This study confirms CBA

Area of Science:

  • Orthopedics
  • Spinal Surgery
  • Regenerative Medicine

Background:

  • Cellular bone allograft (CBA) shows promise in spinal fusion.
  • Limited data exists on CBA fusion outcomes stratified by surgical approach.
  • This study evaluates CBA effectiveness in lumbar spinal fusion across different surgical approaches.

Purpose of the Study:

  • To investigate the effectiveness of CBA in lumbar spinal fusion.
  • To compare fusion outcomes of CBA across anterior, lateral, and posterior surgical approaches.
  • To analyze clinical outcomes including quality of life, disability, and pain.

Main Methods:

  • Prospective, multi-center, open-label clinical study (NCT02969616) involving patients undergoing lumbar spinal fusion with CBA.
  • Fusion status assessed via independent review of dynamic radiographs and CT images.
Keywords:
Trinity Elitearthrodesiscellular allograftcellular bone allograftlumbar fusion

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  • Clinical outcomes measured using EQ5D, Oswestry Disability Index (ODI), and visual analog scale (VAS) for pain, with data analyzed up to 24 months.

    • Main Results:

    • High fusion success rates observed: 98.5% at 12 months and 98.9% at 24 months.
    • Fusion success rates were consistently high across anterior (98.1%-97.9%), lateral (100.0%), and posterior (97.9%-98.8%) approaches.
    • Significant improvements in quality of life, disability, and pain scores were reported (P < 0.0001).

    Conclusions:

    • CBA is an effective alternative to autograft for spinal fusion, yielding high fusion rates.
    • The surgical approach did not significantly impact fusion success rates with CBA.
    • CBA use in spinal fusion demonstrates a favorable safety profile and improves patient outcomes.