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Electromechanical Assessment of Optogenetically Modulated Cardiomyocyte Activity
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An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function.

Olurotimi A Bolonduro1, Zijing Chen2, Corey P Fucetola1

  • 1Department of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 26, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel bioelectronic platform for controlling heart cell (cardiomyocyte) beating using light. This system enables precise, long-term monitoring and stimulation, paving the way for advanced cardiac therapies.

Keywords:
bioelectronicscardiomyocyteselectrophysiologymulti‐electrode arraysoptogenetics

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Area of Science:

  • Bioelectronic Medicine
  • Cardiovascular Research
  • Optogenetics

Background:

  • Bioelectronic medicine offers a promising avenue for restoring physiological functions and treating cardiac disorders.
  • Integrated systems combining cellular function modulation and recording enhance therapeutic efficacy and patient-specific customization.

Purpose of the Study:

  • To develop and demonstrate an integrated optogenetic and bioelectronic platform for stable, long-term stimulation and monitoring of cardiomyocyte function.
  • To investigate the dose-dependent and time-limited effects of optogenetic stimulation on cardiomyocyte beating rate.

Main Methods:

  • Utilized a photoactivatable adenylyl cyclase expressed in cardiomyocytes for optical stimulation with blue light.
  • Employed a multi-electrode array for real-time electrophysiological recording at 32 distinct locations.
  • Quantified changes in cardiomyocyte beating rate in response to varying light intensities and durations.

Main Results:

  • Blue light irradiation (27 µW mm⁻²) induced a stable 14% increase in cardiomyocyte beating rate within 20-25 minutes, sustained for over 2 hours.
  • Cardiomyocyte beating rate demonstrated a monotonic response to light intensity and could be reversibly controlled ('on'/'off' states).
  • The platform was successfully adapted to stretchable and flexible substrates.

Conclusions:

  • The integrated optogenetic and bioelectronic platform provides precise, long-term control and monitoring of cardiomyocyte function.
  • This technology holds significant potential for developing closed-loop systems for cardiac regulation and intervention, particularly for arrhythmias.
  • The adaptable nature of the platform opens new possibilities in the field of bioelectronic medicine.