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Shorter leukocyte telomere length (LTL) is linked to an increased risk of erectile dysfunction (ED). Maintaining longer LTL may help reduce the likelihood of developing ED in aging men.

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Area of Science:

  • Biogerontology
  • Men's Health
  • Aging Biomarkers

Background:

  • Leukocyte telomere length (LTL) is a key indicator of biological aging.
  • Erectile dysfunction (ED) is prevalent in middle-aged and older men.
  • The relationship between LTL and ED requires further investigation.

Purpose of the Study:

  • To investigate the association between leukocyte telomere length (LTL) and erectile dysfunction (ED).

Main Methods:

  • Utilized National Health and Nutrition Examination Survey (NHANES) data.
  • Employed weighted multivariate regression and restricted cubic spline (RCS) analyses.
  • Conducted subgroup and sensitivity analyses for robustness.

Main Results:

  • A significant negative correlation was found between LTL and ED risk.
  • Shorter LTL was associated with a higher prevalence of ED.
  • Each unit increase in LTL reduced ED risk by 54% (OR 0.46, 95% CI 0.25-0.85).
  • Longest LTL quartile showed a 44% lower ED risk than the shortest (OR 0.56, 95% CI 0.39-0.81).
  • A non-linear relationship between LTL and ED was observed.

Conclusions:

  • Shorter LTL is negatively associated with ED.
  • Strategies to preserve LTL may mitigate ED risk.