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Related Experiment Video

Updated: Jun 19, 2025

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Physiology of Cellular Prion Proteins in Reproduction.

Željko M Svedružić¹, Chongsuk Ryou², Donchan Choi³

¹Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia.

Development & Reproduction

|July 26, 2024

Summary

Cellular prion protein (PrP^C) plays roles in various cells, including reproductive organs. This review summarizes its known functions, particularly in reproduction, despite knockout models showing no obvious reproductive phenotypes.

Keywords:

Cellular prion protein Knockout Reproduction Scaffold Scrapie PrP

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Area of Science:

Neuroscience
Cell Biology
Reproductive Biology

Background:

Cellular prion protein (PrP^C), encoded by the Prnp gene, can misfold into pathogenic scrapie PrP (PrP^SC) causing neurodegenerative diseases.
PrP^C is implicated in various cellular interactions and functions, including as a scaffold in the mitochondrial inner membrane.
PrP^C is expressed in reproductive organs, yet knockout models lack clear developmental or reproductive phenotypes.

Purpose of the Study:

To review the known cellular and tissue-specific roles of PrP^C.
To emphasize the functions of PrP^C related to reproduction.

Main Methods:

Literature review of studies on PrP^C function.
Analysis of PrP^C expression and roles in various cell types and tissues.
Focus on reproductive system implications.

Main Results:

PrP^C exhibits diverse cellular roles and interactions.
Expression of PrP^C is noted in reproductive tissues.
Knockout studies have not revealed significant reproductive phenotypes.

Conclusions:

PrP^C has established cellular functions, with expression in reproductive organs.
Further research is needed to elucidate the precise roles of PrP^C in reproduction at the cellular level.