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An epidemiological study of multisystem inflammatory syndrome in children (MIS-C) and young adults among

Shruti Aggarwal1, Jasninder Singh Dhaliwal2, Nomesh Kumar3

  • 1Guru Gobind Singh Medical College, Sadiq Road, Faridkot, India.

Reumatologia
|July 26, 2024
PubMed

Insights

Multisystem inflammatory syndrome in children (MIS-C) affects 4.0% of COVID-19-positive children. Incidence is highest in 8-year-olds, Asian/Pacific Islanders, and males, with some cases resembling Kawasaki disease.

Area of Science:

  • Pediatric infectious diseases
  • Epidemiology
  • Public health

Background:

  • The COVID-19 pandemic led to the emergence of a new pediatric condition, multisystem inflammatory syndrome in children (MIS-C).
  • MIS-C presents with a range of clinical symptoms in children exposed to SARS-CoV-2.

Purpose of the Study:

  • To investigate the associations between sex, race, and age and the incidence of MIS-C among pediatric COVID-19 patients.
  • To determine the prevalence of MIS-C in relation to demographic factors in children.

Main Methods:

  • Utilized the 2021 National Inpatient Sample database.
  • Analyzed data from 69,440 COVID-19-positive children.
  • Examined demographic data (sex, race, age) and MIS-C diagnosis.

Main Results:

  • A total of 2,790 children (4.0%) were diagnosed with MIS-C.
  • Highest MIS-C incidence observed in 8-year-olds (17,130 per 100,000), Asian or Pacific Islanders (5,346 per 100,000), and males (4,734 per 100,000).
  • Approximately 7.9% of MIS-C cases exhibited characteristics of Kawasaki disease.

Conclusions:

  • Demographic factors including age, race, and sex are associated with MIS-C incidence in children.
  • Specific age groups (8-year-olds), ethnicities (Asian/Pacific Islanders), and sexes (males) show higher susceptibility.
  • A notable proportion of MIS-C cases share features with Kawasaki disease, highlighting diagnostic and clinical considerations.

Keywords:
COVID-19United Statesepidemiologymultisystem inflammatory syndrome in children

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