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Aldo-keto reductases: Role in cancer development and theranostics
Siddavaram Nagini1, Prathap Reddy Kallamadi2, Kranthi Kiran Kishore Tanagala3
1World Neem Organization, Mumbai, 400101, India.
Aldo-keto reductases (AKRs) are enzymes involved in cancer development and drug resistance. Inhibiting these enzymes, like aldose reductase (AR), offers a promising strategy for novel cancer therapies.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Aldo-keto reductases (AKRs) are crucial enzymes in cellular metabolism.
- Aberrant AKR expression is linked to cancer development and progression.
- AKRs contribute to cancer hallmarks and chemoresistance.
Purpose of the Study:
- To review the physiological roles of human AKRs.
- To discuss AKR involvement in cancer hallmarks and oncogenic signaling.
- To summarize the potential of AKR inhibitors as anticancer agents.
Main Methods:
- Literature review of AKR functions and cancer involvement.
- Analysis of AKR expression in various malignancies.
- Evaluation of AKR inhibitors in preclinical and clinical studies.
Main Results:
- AKRs are dysregulated in many cancers, promoting oncogenic pathways.
- AKR inhibition can overcome chemoresistance and sensitize cancer cells.
- Both synthetic and natural AKR inhibitors show anticancer potential.
Conclusions:
- AKRs are significant targets for cancer therapy.
- Aldose reductase inhibitors (ARIs) represent a viable therapeutic option.
- Targeting AKRs offers a promising avenue for novel oncotherapeutic strategies.
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