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Related Experiment Video

Updated: Jun 19, 2025

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Automated Continuous Crystallization Platform with Real-Time Particle Size Analysis via Laser Diffraction.

Sayan Pal1, Arun Pankajakshan1, Maximilian O Besenhard1

  • 1Department of Chemical Engineering, University College London, Torrington Place, London WC1E 7JE, U.K.

Organic Process Research & Development
|July 26, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces an automated crystallization platform for real-time particle size analysis, overcoming bottlenecks in pharmaceutical manufacturing. The system enables rapid screening of crystallization parameters and crystallizer designs with minimal experimental effort.

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Area of Science:

  • Pharmaceutical Engineering
  • Chemical Engineering
  • Process Automation

Background:

  • Particulate processes and suspension handling pose automation challenges in the pharmaceutical industry.
  • Antisolvent crystallization development is hindered by time-intensive experimental screening.

Purpose of the Study:

  • To demonstrate a fully automated modular crystallization platform.
  • To overcome bottlenecks in real-time particle size analysis and experimental screening.

Main Methods:

  • Integrated automated crystallization, sample preparation, and online laser diffraction (LD) analysis.
  • Utilized LabVIEW, Python, and PharmaMV software with logic algorithms for automated control.
  • Employed a confined impinging jet crystallizer for ibuprofen antisolvent crystallization.

Main Results:

  • Successfully screened crystallization process parameters and crystallizer design spaces with minimal experimental effort.
  • Achieved automated operation and real-time crystal size distribution visualization.
  • Demonstrated automated dilution to avoid multiple scattering events during LD measurements.

Conclusions:

  • The developed platform significantly accelerates the screening of antisolvent crystallization processes.
  • Enables efficient automation of particle size analysis in pharmaceutical manufacturing.
  • Offers a robust solution for optimizing crystallizer design and process parameters.