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Melatonin attenuates scopolamine-induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway

Xiao-Qi Liu1,2,3,4, Shun Huang5,6, Jia-Yi Zheng1,2,3,4

  • 1State Key Laboratory of Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.

CNS Neuroscience & Therapeutics
|July 26, 2024
PubMed
Summary

Melatonin can improve cognitive dysfunction and anxiety caused by scopolamine. This neuroprotective effect is mediated by the SIRT1/IRE1α/XBP1 pathway, highlighting melatonin as a potential dementia treatment.

Keywords:
ER stressSIRT1cognitive impairmentmelatoninscopolamine

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