Cystic fibrosis year in review 2023

Area of Science:

• Medical Research
• Pulmonology
• Genetics

Background:

• Cystic Fibrosis (CF) affects multiple organs, necessitating continuous research for improved patient outcomes.
• Significant research publications emerged in 2023, focusing on therapeutic and diagnostic advancements.

Purpose of the Study:

• To review key 2023 publications on cystic fibrosis.
• To identify research likely to influence clinical practice and patient care.

Main Methods:

• Literature review of 2023 publications.
• Focus on studies impacting clinical management and patient outcomes.

Main Results:

• Further evaluation of highly effective modulator therapies for CF.
• New guidelines and assessments for CF clinical manifestations and treatments.
• Advances in newborn screening and diagnostic approaches.
• Outcomes assessment for CF transmembrane conductance regulator-related metabolic syndrome/CF screen positive, inconclusive diagnosis.

Conclusions:

• The reviewed 2023 publications indicate potential shifts in clinical care for cystic fibrosis.
• Ongoing research continues to refine the management and diagnosis of CF and related conditions.